Proper hydration is critical on GLP-1 medications. Reduced appetite often means drinking less, while side effects like nausea and constipation can worsen dehydration. Here's how to stay properly hydrated during treatment.
Why Hydration Matters More on GLP-1s
- Reduced thirst: GLP-1s can decrease thirst sensation
- Less food intake: You get less water from food when eating less
- Constipation risk: Dehydration worsens GLP-1 constipation
- Nausea management: Proper hydration can reduce nausea
- Kidney protection: Adequate fluids support kidney function
- Energy levels: Even mild dehydration causes fatigue
How Much Water Do You Need?
A general guideline is to drink half your body weight in ounces daily. For a 200-pound person, that's 100 ounces (about 3 liters). Adjust upward for exercise, heat, or if experiencing vomiting or diarrhea.
Body WeightDaily Water Goal
150 lbs75 oz (2.2L)
200 lbs100 oz (3L)
250 lbs125 oz (3.7L)
Smart Hydration Strategies
- Drink between meals: Large amounts with food can worsen nausea
- Set reminders: Don't rely on thirst—it may be suppressed
- Start the day with water: Drink 16 oz before anything else
- Carry a water bottle: Visual reminder to keep drinking
- Track intake: Use an app or marks on your bottle
- Flavor your water: Lemon, cucumber, or sugar-free flavoring
- Include electrolytes: Especially if experiencing nausea or diarrhea
Signs of Dehydration
Watch for dark urine, headaches, dizziness, dry mouth, fatigue, and reduced urination. If you experience severe dehydration with vomiting, seek medical attention—you may need IV fluids.