Best Vitamins to Take While on Semaglutide
Reduced food intake on semaglutide can lead to nutrient gaps. Learn which vitamins and supplements help prevent deficiencies and support overall health during weight loss.
The Quick Answer: Key supplements for semaglutide users include a quality multivitamin, B12, vitamin D3, protein powder, and biotin. Protein is especially important—aim for 60-100g daily to preserve muscle mass during weight loss.
Get Comprehensive Weight Loss Support
These providers include nutritional guidance as part of their programs.
CoreAge Rx
Premium GLP-1 Weight Loss Program
- FDA-approved GLP-1 medications
- Personalized treatment plans
- Board-certified physicians
Mochi Health
Meds start at $99/mo, No Long-Term Commitment
- Book a Live Video Visit in 5 Minutes
- Reliable GLP-1 Prescription Access, All 50 states
- 24/7 Support + Ongoing Appointments
Ro
December Sale: Get Started Online for Just $45
- FDA-Approved GLP-1s at Half the Usual Price
- Access to Ozempic®, Tirzepatide & Semaglutide
- Lose 10%–26% Body Weight Within 12 Months
Why Vitamins Are Important on Semaglutide
When you eat significantly less food, you naturally consume fewer vitamins and minerals. Semaglutide also slows digestion, which can affect nutrient absorption. Key concerns include:
- Reduced protein intake leading to muscle loss
- Lower intake of essential vitamins and minerals
- Potential B12 deficiency with long-term use
- Increased risk of hair loss from nutrient deficiencies
Essential Vitamins for Semaglutide Users
1. Quality Multivitamin
A good daily multivitamin provides baseline coverage for most essential nutrients. Look for one with methylated B vitamins for better absorption.
Priority: Essential
2. Vitamin B12
GLP-1 medications can reduce B12 absorption. Symptoms of deficiency include fatigue, weakness, and cognitive issues. Consider sublingual B12 for better absorption.
Priority: High — especially important for vegetarians
3. Vitamin D3
Many people are already deficient in vitamin D. It's essential for bone health, immune function, and mood. Take with a meal containing fat for better absorption.
Priority: High — most people benefit from supplementation
4. Protein Supplement
Adequate protein is crucial to preserve muscle mass during weight loss. If you struggle to eat enough protein, consider a quality protein powder (whey, collagen, or plant-based).
Priority: High — aim for 0.7-1g protein per pound of body weight
5. Biotin
Many semaglutide users experience hair thinning due to rapid weight loss and reduced nutrient intake. Biotin supports hair, skin, and nail health.
Priority: Medium — especially if noticing hair changes
6. Omega-3 Fatty Acids
Fish oil or algae-based omega-3s support heart health, reduce inflammation, and may help with joint stiffness some users experience during rapid weight loss.
Priority: Medium — beneficial for overall health
Tips for Taking Supplements on Semaglutide
Take vitamins with whatever food you do eat to improve absorption
Choose gummy or liquid vitamins if nausea makes pills difficult
Spread supplements throughout the day rather than all at once
Ask your doctor about periodic blood work to check nutrient levels
Consult Your Healthcare Provider
Before starting any supplement regimen, discuss your plans with your doctor. They can recommend specific dosages based on your individual needs and may suggest blood tests to identify any existing deficiencies.