He & She MD Review
Headline prices need a twelve-month prepay, and it sells oral GLP-1
Injectable semaglutide $139/month, or $99 on twelve-month supply; tirzepatide from $159
Overview
He & She MD is a telehealth clinic covering weight loss, longevity, hormone therapy, sexual wellness, hair and performance, with GLP-1 pricing that looks excellent until you read the asterisk. Injectable semaglutide is listed at $199 a month reduced to $139, and at $99 a month — but that figure, like the $159 tirzepatide rate, applies to a twelve-month supply purchase. There is no membership cost, pricing is flat at every dose, shipping is free and expedited, and a board-certified US physician or DO reviews each intake. Two things hold the rating down. The advertised prices require committing to a year of a medication you may not tolerate past week three. And it sells oral semaglutide and oral tirzepatide, a category with no established bioavailability evidence outside one specific FDA-approved tablet formulation.
Pros
- Injectable semaglutide from $139/month, or $99 on a twelve-month supply
- Tirzepatide from $159/month on a twelve-month supply
- No membership cost or hidden fees; same price at every dose
- Free expedited shipping on every order
- Board-certified US physician or DO reviews each intake
- Brand-name FDA-approved options also offered
Cons
- Best advertised prices require buying a twelve-month supply upfront
- Sells oral semaglutide and oral tirzepatide with no established bioavailability evidence
- Brand-name pricing at $1,299–$1,399/month is above manufacturer-direct programmes
- Compounding pharmacies described as licensed but not named
- No lab work described as part of the programme
- Compounded medications are not FDA-approved as finished products
Key Features
Best For
Patients confident enough in tolerating a GLP-1 to commit to a twelve-month supply for the lowest rate
He & She MD at a Glance
Everything below reflects what He & She MD published on its own site as of August 24, 2026. Where a detail is not published, we say so rather than guessing.
- • Compounded injectable semaglutide
- • Compounded injectable tirzepatide
- • Oral semaglutide
- • Oral tirzepatide
- • Brand-name FDA-approved GLP-1 medications
Pricing
Injectable semaglutide is listed at $199 a month reduced to $139, with $99 a month available on a twelve-month supply purchase. Injectable tirzepatide is $159 on the same twelve-month basis. Oral semaglutide is $209 and oral tirzepatide $269, also on twelve-month pricing. Brand-name options are quoted at $1,299 and $1,399. The asterisked figures all depend on buying a year at once, which is a substantial commitment for a medication whose tolerability you will not know until several weeks in.
Membership fees
None — stated as no membership cost or hidden fees.
Medication fees
- • Injectable semaglutide: $199/month, reduced to $139; $99/month on twelve-month supply
- • Injectable tirzepatide: $159/month on twelve-month supply
- • Oral semaglutide: $209/month on twelve-month supply
- • Oral tirzepatide: $269/month on twelve-month supply
- • Brand-name options: $1,299–$1,399/month
Prices change often in this category. Always confirm the current cost — including what you will pay after any introductory or promotional period — directly with He & She MD before enrolling.
Cancellation, Refunds & Payment
Support Services
Limitations to Know
- Advertised rates require a twelve-month supply purchase
- Oral GLP-1 products lack established bioavailability evidence
- Cancellation and refund terms unpublished — significant given annual prepay
- Pharmacies unnamed; 503A versus 503B status unstated
- No lab monitoring described
Alternatives to He & She MD
From $99/month on annual plans too, but publishes its 503A status and refund terms explicitly.
$69 semaglutide and $119 tirzepatide with no annual commitment and a stated refund policy.
Flat $139.99/month with no long commitment and eleven clinicians named with NPI numbers.
Still comparing? See our full ranking of online GLP-1 providers.
He & She MD FAQs
Do I have to buy twelve months upfront?
For the lowest advertised prices, yes — the $99 semaglutide and $159 tirzepatide figures are marked as applying to a twelve-month supply. Injectable semaglutide is available at $139 a month without that. Since cancellation and refund terms are not published, confirm them before committing to a year of a medication you have not taken before.
Does oral semaglutide or tirzepatide work?
There is one FDA-approved oral semaglutide tablet, which relies on a specific absorption enhancer and a strict fasting protocol to reach roughly one percent bioavailability. No oral or sublingual tirzepatide is FDA-approved in any form, and compounded oral peptides generally lack established absorption evidence. If needles are the obstacle, ask about injection technique first — GLP-1 injections use a very fine subcutaneous needle.
How much does He & She MD cost?
Injectable semaglutide is $139 a month, or $99 on a twelve-month supply. Tirzepatide is $159 on twelve months. Oral products are $209 and $269. Brand-name options are $1,299 to $1,399. There is no membership fee and pricing is flat at every dose.
Should I buy brand-name medication here?
Compare first. At $1,299 to $1,399 a month, check manufacturer-direct self-pay programmes for the same FDA-approved products, which are frequently substantially lower, and check whether your insurance covers the category at all.
Sources consulted
Medical disclaimer: This review is for educational and comparison purposes only and is not medical advice. Rx Saver Hub is not a medical provider and does not prescribe medication. Compounded medications are not FDA-approved, and the FDA does not evaluate their safety, effectiveness or quality. Program details, pricing and availability change frequently — verify everything directly with He & She MD. Always consult a qualified healthcare provider before starting, stopping or changing any weight-loss treatment. Individual results vary.
He & She MD
Injectable semaglutide $139/month, or $99 on twelve-month supply; tirzepatide from $159
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