Best Compounded GLP-1 Providers 2026
Compounded semaglutide and tirzepatide cost a fraction of the brand-name versions, which is why most online weight-loss programs sell them. But compounded drugs are not FDA-approved, and the FDA does not evaluate their safety, effectiveness or quality — so the pharmacy behind your vial matters enormously. We ranked these providers primarily on one question: how much do they actually tell you?
The Quick Answer
Trimi Health ranks first: it names both its 503A pharmacies and its clinical network, and charges one all-in fee. Shapely pairs clear 503A/503B disclosure with the most clinical structure, and Aspire Health is the most candid about what compounded status actually means.
Not sure compounded is right for you? Read compounded vs brand-name GLP-1 first.
FDA actions affecting a provider on this page
FDA has issued warning letters to telehealth companies over false or misleading claims about compounded GLP-1 products. One provider ranked on this page received one. A warning letter is FDA's stated position that violations occurred — not a court finding, a recall, or a determination that any patient was harmed — and companies often correct the cited material.
- OrderlyMeds — FDA warning letter, June 8, 2026 (MARCS-CMS 728291). Read it on fda.gov →
We keep these providers listed because their published details are still worth comparing, and we disclose the action so you can weigh it yourself. You can search any company in FDA's warning letter database.
Our Picks, Ranked
Trimi Health
All-in $99/month with named 503A pharmacies and overnight shipping
Trimi names its 503A partner pharmacies — VialsRx and GreenwichRx — and names the clinical network behind its prescribers, Arora Health, which almost nobody in this category does. It pairs that with the cleanest pricing here: $99/month for compounded semaglutide and $125 for tirzepatide covering medication, clinician visits, check-ins and free overnight shipping in one fee, across all 50 states, FSA/HSA eligible. The rates are quoted on annual plans.
Pricing: All-in from $99/month on an annual plan
Pros
- One flat fee covers medication, visits, check-ins and shipping
- Names its 503A partner pharmacies (VialsRx and GreenwichRx)
- Compounded semaglutide $99/month, tirzepatide $125/month
- Available in all 50 states
Cons
- Headline pricing is tied to annual plans
- Month-to-month pricing is not published
- Lab requirements are not published
- Cancellation and refund terms are not published
OrderlyMeds is the only provider we found that names the pharmacies filling its prescriptions — SmartPharmaRx, Casa and PerfectionRx/PerfectRx — and identifies them as 503A pharmacies led by credentialed pharmacists. It also publishes both the intro rate and the ongoing rate, so the step-up from $74 to $149/month on semaglutide is visible before you sign up. Providers are licensed in all 50 states. In June 2026 FDA issued OrderlyMeds a warning letter (MARCS-CMS 728291) over claims about compounded GLP-1 products on orderlymeds.com; read it before deciding.
Pricing: From $74 first month, $149/month thereafter
Pros
- Names its partner pharmacies rather than describing them vaguely
- Publishes both intro pricing and the ongoing rate
- Providers licensed in all 50 states
- No separate membership fee disclosed
Cons
- Price roughly doubles after the introductory month
- Lab requirements are not published
- Cancellation and refund terms are not published
- Does not accept insurance
Shapely names its pharmacy category clearly — state-licensed 503A and 503B compounding pharmacies — and wraps the medication in real clinical structure: monthly video visits, monthly dietitian visits, recent labs strongly recommended at a $75 flat rate, and a smart scale. Compounded semaglutide starts at $99/month and tirzepatide at $166/month.
Pricing: Membership $99/month (promo $49) + medication from $99/month
Pros
- In network with Medicare and most PPO plans for visits
- Compounded semaglutide starts at $99/month
- Publishes dose-tiered medication pricing openly
- Flat $75 lab rate for uninsured patients
Cons
- Available in only four states
- $99/month membership required on top of medication
- Compounded medications are not reimbursed by insurance
- Cancellation and refund terms are not published
Aspire Health
Per-dose vial pricing, free consultation, $49/month care fee
Aspire states outright that its compounded medications have not undergone the same FDA review for safety, efficacy or manufacturing quality as commercially manufactured drugs — the clearest disclosure we encountered. It backs that with per-vial pricing at every dose ($129–$189 semaglutide, $149–$299 tirzepatide), a free consultation and HSA/FSA acceptance.
Pricing: $49/month care + compounded medication from $129 per vial
Pros
- Publishes per-vial pricing at every dose level
- Free new patient consultation
- Low $49/month medical care fee
- HSA and FSA cards accepted for services and compounded medications
Cons
- Insurance not accepted for visits
- Consultation fees generally non-refundable once a provider has reviewed your case
- All medication sales are final once shipped
- Available in a limited set of states
Ivím works with FDA-inspected, state-regulated compounding pharmacies and states plainly that compounded semaglutide is not FDA-approved. Its $74.99/month membership includes unlimited 1:1 provider consults, 24/7 care team access and functional nutritional counseling, and it confirms HSA/FSA cards are accepted despite the lack of insurance coverage.
Pricing: Membership $74.99/month + compounded semaglutide from $149/month
Pros
- Compounded semaglutide starts at $149/month
- Free initial provider consultation
- Unlimited 1:1 provider consults included in membership
- HSA and FSA cards accepted
Cons
- $74.99/month membership is among the higher fees in this category
- Compounded semaglutide is not covered by insurance
- Lab requirements, shipping details and states served are not published
- Refund terms are behind a policy link rather than stated on the page
Lemonaid Health
Brand-name and compounded GLP-1s with published price tiers
Lemonaid is useful precisely because it sells both routes and prices them side by side: compounded semaglutide and tirzepatide from $199–$299/month against brand-name Ozempic at $1,199 and Wegovy at $1,599. Seeing both on one page makes the real trade-off legible. It does not, however, publish its pharmacy partners.
Pricing: Membership $49/month + medication from $199/month
Pros
- Publishes medication prices openly instead of requiring a quiz first
- Offers both compounded and brand-name GLP-1 options
- Lower-cost microdose plans at $199/month
- Multi-month plans reduce the monthly medication cost
Cons
- $49/month membership is charged on top of medication
- Cash-pay only — no insurance accepted for any fees
- Not yet available in all 50 states
- Does not publish its pharmacy partners or shipping cadence
24hrdoc offers compounded semaglutide as weekly injections at $149/month, oral semaglutide as tablets or drops at $179/month, compounded tirzepatide at $239/month, and a separate clinically supervised microdosing protocol. It states clearly that it is not a pharmacy and that licensed pharmacies handle fulfilment. FSA/HSA accepted.
Pricing: From $149/month (sale price; regularly $249)
Pros
- Injectable, oral and microdose GLP-1 formats all available
- Shows sale and regular pricing side by side
- FSA and HSA accepted for most patients
- Fast and free discreet shipping
Cons
- Does not accept insurance for weight-loss treatment
- Not a pharmacy — does not carry or ship medicines itself
- Available in most, but not all, U.S. states
- Lab requirements and refund terms are not published on the program page
TrimRx
Compounded GLP-1s with labs and unlimited support from $179/month
TrimRx bundles doctor consultations, lab work and unlimited support into plans advertised from $179/month, and says its medications come from FDA-registered and inspected pharmacies. Including labs is genuinely uncommon here. The offsetting problem is verification — TrimRx publishes very little beyond that headline, with no dose-level pricing or state list.
Pricing: Plans from $179/month
Pros
- Lab work bundled into the program rather than billed separately
- Doctor consultations and unlimited support included
- Free assessment quiz to check eligibility
- Medications sourced from FDA-registered and inspected pharmacies
Cons
- Very little detail published beyond the $179/month headline
- No medication-by-medication price breakdown
- States served are not published
- Shipping, insurance, HSA/FSA, cancellation and refund terms are not published
Brello advertises compounded semaglutide with B6 at $133/month and a 3-month plan cut from $599 to $399, and states directly that compounded drug products are not FDA-approved. Weigh that against its structure: payment is taken before the medical intake, and refunds close 24 hours after provider review, minus a $50 professional services fee.
Pricing: $133/month special; 3-month plan $399
Pros
- Among the lowest advertised compounded semaglutide prices at $133/month
- 3-month plan discounted from $599 to $399
- Includes app support, virtual fitness and nutrition classes
- Cancel at any time
Cons
- You pay before completing the medical intake form
- Refunds carry a $50 professional services fee
- Refund window is only 24 hours after provider review
- States served are not listed on the product page
Side-by-Side Comparison
| Provider | Rating | Pricing | Best for |
|---|---|---|---|
| Trimi Health | 8.5/10 | All-in from $99/month on an annual plan | Patients who want a single all-inclusive price and are comfortable committing to an annual plan |
| OrderlyMeds | 8.3/10 | From $74 first month, $149/month thereafter | Patients who want to know exactly which pharmacy compounds their medication before ordering |
| Shapely | 8.6/10 | Membership $99/month (promo $49) + medication from $99/month | Patients in CA, FL, NY or TX who want insurance-billed visits, real dietitian support, and published prices |
| Aspire Health | 8.1/10 | $49/month care + compounded medication from $129 per vial | Cost-conscious patients who want to know what every dose step will cost before they titrate up |
| Ivím Health | 8.4/10 | Membership $74.99/month + compounded semaglutide from $149/month | Patients who want heavy clinician contact and nutrition support alongside affordable compounded medication |
| Lemonaid Health | 8.7/10 | Membership $49/month + medication from $199/month | Shoppers who want to compare compounded and brand-name GLP-1 pricing openly before starting |
| 24hrdoc | 8/10 | From $149/month (sale price; regularly $249) | Patients who want an oral or microdose GLP-1 option and plan to pay with an FSA or HSA card |
| TrimRx | 7.2/10 | Plans from $179/month | Patients who want labs and support bundled into one monthly price and will ask for the details directly |
| Brello Health | 7.6/10 | $133/month special; 3-month plan $399 | Price-driven shoppers comfortable paying up front and reading the refund terms closely first |
Pricing in this category changes frequently and promotional rates often differ from renewal rates. Confirm current costs directly with each provider before enrolling.
What Compounded Actually Means
A compounded medication is prepared by a pharmacy rather than manufactured by the drug's original maker. The pharmacy combines the active ingredient into a finished product — sometimes with additives such as B6 or B3 that are not part of the FDA-approved version.
The critical distinction: compounded drugs are not FDA-approved. The FDA does not review them for safety, effectiveness or manufacturing quality. Several of the providers on this page say so on their own websites, and that candour is part of why they rank where they do.
Two pharmacy categories come up repeatedly. 503A pharmacies compound for individual patients against a specific prescription. 503B outsourcing facilities compound in larger batches and are subject to additional FDA oversight. Shapely cites both categories; OrderlyMeds cites 503A specifically.
FDA Has Been Warning Telehealth Companies — Here's How to Check
This is the single most useful vetting tool most people do not know exists. FDA publishes every warning letter it issues, in a searchable database, and it has been issuing them to telehealth companies over claims made about compounded GLP-1 products.
In September 2025 FDA sent a batch of letters to telehealth firms and, in a further round dated June 8, 2026, issued another set over false or misleading promotional claims about compounded GLP-1s. Named companies across those rounds include OrderlyMeds, Maximus, Hims & Hers (under its Hers brand), MEDVi, WeightCare, Ready Med and Medica Weight Loss, among others.
What a warning letter is: FDA's stated position that violations occurred, usually about how a product was marketed. What it is not: a court finding, a recall, or evidence that a specific patient was harmed. Companies routinely respond and correct the cited material, sometimes within weeks.
Check any provider yourself before enrolling — it takes about a minute:
- Open FDA's warning letter database and search the company name — and its legal entity name, which is often different from the brand.
- Search the term telehealth to see the letters sent to this sector, as FDA itself suggests in its guidance page for telehealth companies promoting compounded drugs.
- Match on the entity and website, not a similar name. “Medica Weight Loss” and “Medi-Weightloss” are different companies, as are “Ready Med” and “ReadyRx”.
- Read what the letter actually alleges. A claim-wording problem is a different thing from a sterility or dosing problem.
Where a provider we review has received one, we say so on their review page with a link to the letter, rather than quietly leaving it out.
How to Vet a Compounded GLP-1 Provider
Ask these questions before you pay. A provider that will not answer them in writing is telling you something:
- Which pharmacy compounds my medication? A name is better than a category. A category is better than nothing.
- Is it 503A or 503B, and is it licensed in my state?
- What exactly is in the formulation? Additives such as B6, B3 or ondansetron are common and are not part of the FDA-approved product.
- What will I pay at my maintenance dose? Not the starter dose — the dose you will settle on months from now.
- What happens if I am declined after paying? Brello Health, for example, refunds within 24 hours of provider review minus a $50 fee.
- Who do I contact about a side effect? Unlimited provider messaging is meaningfully different from an email address.
Compounded Pricing Compared
Published compounded prices across the providers we researched, taken from their own sites:
- Semaglutide: OrderlyMeds $74 first month then $149 · OurView $75 · Trimi $99 all-in · Shapely from $99 · Citizen Meds $125 · Aspire $129–$189 per vial · Brello $133 · Ivím from $149 · 24hrdoc $149 · Call-On-Doc $250 · Lemonaid $299
- Tirzepatide: Trimi $125 all-in · OurView $135 · Citizen Meds $145 · Aspire $149–$299 per vial · OrderlyMeds $149 first month then $299 · Shapely from $166 · 24hrdoc $239 · Ivím from $250 · Heally from $299 · Lemonaid $299 ($229 on a 6-month plan)
Remember to add membership fees where they apply: $19.99/month at PlushCare, $49 at Lemonaid and Aspire, $74.99 at Ivím, and $99 at Shapely. A low medication price plus a high membership can cost more than the reverse.
Frequently Asked Questions
Are compounded GLP-1 medications safe?
Compounded medications are not FDA-approved, and the FDA does not evaluate their safety, effectiveness or quality — providers including Ivím Health, Aspire Health and Brello Health state this on their own sites. That does not mean they are unsafe, but it does mean the quality assurance rests on the compounding pharmacy rather than FDA review. Discuss the trade-off with a licensed clinician.
Which compounded GLP-1 provider names its pharmacy?
Two do. OrderlyMeds names SmartPharmaRx, Casa and PerfectionRx/PerfectRx, and Trimi Health names VialsRx and GreenwichRx. Others describe pharmacies only by category: Shapely cites state-licensed 503A and 503B pharmacies, Ivím Health cites FDA-inspected state-regulated compounding pharmacies, EllieMD cites 503A-compliant facilities, and TrimRx cites FDA-registered and inspected pharmacies without naming them.
What is the difference between a 503A and 503B pharmacy?
A 503A pharmacy compounds medication for an individual patient against a specific prescription. A 503B outsourcing facility compounds in larger batches and is subject to additional FDA oversight including current good manufacturing practice requirements. Shapely cites both; OrderlyMeds cites 503A.
Why do some compounded GLP-1s include B6 or B12?
Some pharmacies add vitamins such as B6 (pyridoxine) or B3 to the formulation — Brello Health compounds with B6 and Aspire Health with B3. These additives are not part of the FDA-approved product and their clinical rationale should be discussed with the prescribing clinician rather than assumed to be beneficial.
Does insurance cover compounded GLP-1 medications?
Generally no. Shapely states compounded medications are not reimbursed by insurance and Ivím Health states compounded semaglutide is not covered. However, several providers accept HSA and FSA cards for compounded medication, including Ivím Health, Aspire Health and 24hrdoc.
What is the cheapest compounded GLP-1 program?
OrderlyMeds has the lowest entry price at $74 for the first month of compounded semaglutide, rising to $149/month. Shapely starts at $99/month ongoing and Brello Health advertises $133/month. Compare the maintenance-dose price and any membership fee, not just the headline rate.
Medical Disclaimer: This guide is for educational and comparison purposes only and is not medical advice. Rx Saver Hub is not a medical provider and does not prescribe medication. Compounded medications are not FDA-approved, and the FDA does not evaluate their safety, effectiveness or quality. Rankings reflect our editorial assessment of publicly available information, including how much each provider discloses about pricing, pharmacies and clinical process. Always consult a qualified healthcare provider before starting, stopping or changing any weight-loss treatment. Individual results vary.